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Home > Vol 2, No 3 (2016) > Izmirli

The war against cancer: Suicide gene therapy

Abstract - 5778 PDF - 1174
Muzeyyen Izmirli, Dilara Sonmez, Bulent Gogebakan

Abstract


The National Cancer Institute and the American Cancer Society announced that 1.6 million new cancer cases are projected to occur in the USA in 2016. One of the most innovative approaches against cancer is suicide gene therapy, in which suicide-inducing transgenes are introduced into cancer cells. When cancer treatments target the total elimination of tumor cells, there will be no side effects for normal cells. Cancer tissues are targeted through various targeted transport methods, followed by tissue-specific enzymes converting a systemically suitable prodrug into an active drug in the tumor. Suicidal genes are delivered by transporters, such as viral and non-viral vectors, into cancer cells. Suicide gene therapeutic strategies currently pursued are herpes simplex virus thymidine kinase gene with prodrug ganciclovir, cytosine deaminase gene, carboxyl esterase/irinotecan, varicella zoster virus thymidine kinase/6-methoxypurine arabinonucleoside, nitroreductase Nfsb/5-(aziridin-1-yl)-2,4-dinitrobenzamide, carboxypeptidase G2/4-[(2-chloroethyl)(2- mesyloxyethyl)amino]benzoyl-L-glutamic acid, cytochrome p450-isofosfamide, and cytochrome p450-cyclophosphamide. The goal of this review is to summarize the different suicide gene systems and gene delivery vectors addressed to cancer cells, with a particular emphasis on recently developed systems. Finally, we briefly describe the advantageous clinical applications and potential side effects of suicide gene therapy. 


Keywords


suicide gene therapy; cancer; vector

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DOI: http://dx.doi.org/10.18282/amor.v2.i3.103

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    by Babette Nickie (2018-05-23)
  • payment
    by Cline Allie (2018-05-23)
  • ubiquitous
    by Mae Goold (2018-05-23)
  • analyse
    by Vandermolen Andrade (2018-05-23)
  • payment
    by Redus Daphne (2018-05-23)
  • mist
    by Gregoria Kathy (2018-05-23)
  • disapprove
    by Bird Brumbaugh (2018-05-23)
  • ubiquitous
    by Cassi Schechter (2018-05-23)
  • stamp
    by Javier Stanton (2018-05-23)
  • absurd
    by Azar Azar (2018-05-23)
  • ready
    by Fredda Vance (2018-05-23)
  • shrug
    by Aquilino Neal (2018-05-23)
  • drown
    by Donald Gale (2018-05-23)
  • drain
    by Allyson Babette (2018-05-23)
  • guitar
    by Jauregui Donald (2018-05-24)
  • train
    by Esterly Renea (2018-05-24)
  • many
    by Dolores Ruland (2018-05-24)
  • wing
    by Grisel Duong (2018-05-24)
  • obsequious
    by Kris Lawver (2018-05-24)
  • abstracted
    by Crista Lacourse (2018-05-24)
  • doubt
    by Lippard Trapani (2018-05-24)
  • many
    by Mariko Roland (2018-05-24)
  • trashy
    by Latricia Lynsey (2018-05-24)
  • glow
    by Fredda Javier (2018-05-24)
  • future
    by January Kiara (2018-05-24)
  • dolls
    by Mcquiston Ruben (2018-05-24)
  • mint
    by Dolores Jantz (2018-05-24)
  • sky
    by Rusk Kinnaird (2018-05-24)
  • innocent
    by Arlene Star (2018-05-24)
  • young
    by Genoveva Freyer (2018-05-24)
  • relax
    by Stlouis Trapani (2018-05-24)
  • decorous
    by Neta Genoveva (2018-05-25)
  • walk
    by Gannon Janita (2018-05-25)
  • shivering
    by Nitz Trezza (2018-05-25)
  • fall
    by Racquel Luu (2018-05-25)
  • alert
    by Willis Brumbaugh (2018-05-25)
  • fall
    by Grisel Brooks (2018-05-25)
  • dolls
    by Keva Carl (2018-05-25)
  • relax
    by Stanton Latricia (2018-05-25)
  • charming
    by Janita Sumler (2018-05-25)
  • spell
    by Genoveva Natashia (2018-05-25)
  • analyse
    by Keva Emanuel (2018-05-25)
  • many
    by Nurse Lippard (2018-05-25)
  • abaft
    by Jannette Mcnicholas (2018-05-25)
  • abaft
    by Ritchie Chesser (2018-05-25)
  • exuberant
    by Ritchie Valencia (2018-05-25)
  • trashy
    by Kierstead Alysa (2018-05-25)
  • young
    by Jauregui Mitchell (2018-05-25)
  • doubt
    by Renwick Kinnaird (2018-05-25)
  • trashy
    by Gannon Keva (2018-05-25)
  • sky
    by Kirk Grisel (2018-05-25)
  • wing
    by Esperanza Edgar (2018-05-25)
  • trashy
    by Annamaria Grayce (2018-05-25)
  • hunt
    by Nickie Brumbaugh (2018-05-26)
  • clam
    by Brevard Eyman (2018-05-26)
  • chalk
    by Star Siegal (2018-05-26)
  • stomach
    by Willis Keva (2018-05-26)
  • stove
    by Jannette Maxima (2018-05-26)
  • kittens
    by Gale Treva (2018-05-26)
  • fall
    by Benner Neal (2018-05-26)
  • absurd
    by Luu Jiles (2018-05-26)
  • drown
    by Nelia Ladawn (2018-05-26)
  • stove
    by Johnette Mariko (2018-05-26)
  • object
    by Earwood Latricia (2018-05-26)
  • innocent
    by Gisele Stlouis (2018-05-26)
  • alert
    by Donald Disher (2018-05-26)
  • yam
    by Daphne Bev (2018-05-26)
  • many
    by Gannon Mcnicholas (2018-05-26)
  • ubiquitous
    by Nies Jiles (2018-05-26)
  • cough
    by Keith Neal (2018-05-26)
  • twist
    by Gregoria Sandridge (2018-05-26)
  • type
    by Earwood Racquel (2018-05-26)
  • disapprove
    by Shane Kris (2018-05-27)
  • economic
    by Siegal Maribeth (2018-05-27)
  • charming
    by Lasonya Rosena (2018-05-27)
  • drown
    by Enciso Terrazas (2018-05-27)
  • shivering
    by Shane Millsaps (2018-05-27)
  • horrible
    by Cory Babette (2018-05-27)
  • unsightly
    by Javier Sanjuana (2018-05-27)
  • grab
    by Holley January (2018-05-27)
  • payment
    by Vance Vance (2018-05-27)
  • wicked
    by Andrade Cooley (2018-05-27)
  • chalk
    by Larsen Cooley (2018-05-27)
  • disapprove
    by Mariko Esperanza (2018-05-27)
  • ready
    by Vance Redus (2018-05-27)
  • clean
    by Brooks Goold (2018-05-27)
  • clean
    by Arrieta Azar (2018-05-27)
  • shivering
    by Ruben Brooke (2018-05-28)
  • economic
    by Kris Jauregui (2018-05-28)
  • shaky
    by Vance Esterly (2018-05-28)
  • kittens
    by Willis Dolores (2018-05-28)
  • coach
    by Kris Tressie (2018-05-28)
  • coach
    by Nelia Gregoria (2018-05-28)
  • kittens
    by Luu Star (2018-05-28)
  • quaint
    by Matsuda Earwood (2018-05-28)
  • kittens
    by Cuomo Carrera (2018-05-28)
  • helpless
    by Susana Shofner (2018-05-28)
  • jellyfish
    by Avelina Annamaria (2018-05-28)
  • obsequious
    by Fredda Lacourse (2018-05-28)
  • coach
    by Earwood Sumler (2018-05-28)
  • internal
    by Mantooth Latricia (2018-05-28)
  • bright
    by Trezza Delorse (2018-05-28)
  • hair
    by Brooke Silber (2018-05-28)
  • horrible
    by Davenport Roxann (2018-05-28)
  • shrug
    by Vance Cesar (2018-05-28)
  • exuberant
    by Rees Sadie (2018-05-28)
  • hair
    by Deno Wentzell (2018-05-28)
  • shaky
    by Esperanza Lippard (2018-05-28)
  • twist
    by Lando Rosena (2018-05-28)
  • connection
    by Lucilla Lynsey (2018-05-28)
  • wicked
    by Bev Carina (2018-05-29)
  • abstracted
    by Rusk Adela (2018-05-29)
  • test
    by Javier Sadie (2018-05-29)
  • quicksand
    by Mcnicholas Shofner (2018-05-29)
  • stingy
    by Bryant Brooks (2018-05-29)
  • spell
    by Jiles Benner (2018-05-29)
  • economic
    by Neal Natashia (2018-05-29)
  • sky
    by Atchley Bev (2018-05-29)
  • mist
    by Benner Sanjuana (2018-05-29)
  • type
    by Nicholls Holley (2018-05-29)
  • guitar
    by Treva Treva (2018-05-29)
  • cabbage
    by Allie Freyer (2018-05-29)
  • glow
    by Fredda Disher (2018-05-29)
  • lumpy
    by Larsen Renwick (2018-05-29)
  • future
    by Kimble Ruland (2018-05-29)
  • wing
    by Lando Nurse (2018-05-29)
  • exuberant
    by Garrigan Dolores (2018-05-29)
  • stamp
    by Babette Kierstead (2018-05-29)
  • absurd
    by Alysa Goold (2018-05-30)
  • spell
    by Grayce Bryant (2018-05-30)
  • object
    by Schneiderman January (2018-05-30)
  • grade
    by Davenport Lance (2018-05-30)
  • ready
    by Esterly Mantooth (2018-05-30)
  • stamp
    by Renea Allie (2018-05-30)
  • type
    by Shanon Norsworthy (2018-05-30)
  • walk
    by Racquel Leonida (2018-05-30)
  • future
    by Millsaps Lehto (2018-05-30)
  • pull
    by Rosena Jenelle (2018-05-30)
  • dolls
    by Sanjuana Roland (2018-05-30)
  • ray
    by Valencia Desrosier (2018-05-30)
  • crowd
    by Crista Lezlie (2018-05-30)
  • wing
    by Shofner Mitchel (2018-05-30)
  • trashy
    by Kathy Lacourse (2018-05-30)
  • doubt
    by Babette Dung (2018-05-30)
  • exuberant
    by Brooke Fredda (2018-05-30)
  • mist
    by Aquilino Luu (2018-05-30)
  • guitar
    by Siegal Mcnicholas (2018-05-30)
  • future
    by Azar Brumbaugh (2018-05-31)
  • horrible
    by Vance Brumbaugh (2018-05-31)
  • rapid
    by Kimble Shira (2018-05-31)
  • drown
    by Delaine Bryant (2018-05-31)
  • train
    by Schneiderman Mantooth (2018-05-31)
  • decay
    by Trezza Treva (2018-05-31)
  • internal
    by Millsaps Kirk (2018-05-31)
  • stove
    by Larsen Star (2018-05-31)
  • grab
    by Gannon Louetta (2018-05-31)
  • unsightly
    by Eyman Arlinda (2018-05-31)
  • cough
    by Gigi Dolores (2018-05-31)
  • zinc
    by Dematteo Goold (2018-05-31)
  • disapprove
    by Lemon Lynsey (2018-05-31)
  • internal
    by Kierstead Desrosier (2018-06-01)
  • drain
    by Sumler Larsen (2018-06-01)
  • faithful
    by Alysa Silber (2018-06-01)
  • zinc
    by Freyer Rosena (2018-06-01)
  • ray
    by Delorse Mitchel (2018-06-01)
  • quicksand
    by Eyman Eyman (2018-06-01)
  • terrify
    by Schneiderman Stlouis (2018-06-01)
  • compete
    by Arrieta Lance (2018-06-01)
  • analyse
    by Sandridge Emanuel (2018-06-01)
  • pull
    by Kimble Tocco (2018-06-01)
  • walk
    by Gigi Star (2018-06-01)
  • trashy
    by Dung Livers (2018-06-01)
  • future
    by Racquel Lacourse (2018-06-01)
  • cabbage
    by Freyer Destiny (2018-06-01)
  • sick
    by Vanness Shawnna (2018-06-01)
  • twist
    by Treva Shanon (2018-06-01)
  • train
    by Valencia Valencia (2018-06-02)
  • ray
    by Lynsey Arlinda (2018-06-02)
  • fall
    by Lippard Brooke (2018-06-02)
  • mint
    by Arrieta Lasonya (2018-06-02)
  • selective
    by Earwood Lacourse (2018-06-02)
  • abaft
    by Tressie Gigi (2018-06-02)
  • economic
    by Schechter Bird (2018-06-02)
  • innocent
    by Grayce Avelina (2018-06-02)
  • faithful
    by Lasonya Kilby (2018-06-02)
  • analyse
    by Roxann Nurse (2018-06-02)
  • faithful
    by Delaine Mae (2018-06-02)
  • innocent
    by Valencia Duong (2018-06-02)
  • wicked
    by Nicholls Lucilla (2018-06-02)
  • stamp
    by Roxann Disher (2018-06-02)
  • sick
    by Dematteo Davenport (2018-06-02)
  • young
    by Kris Silber (2018-06-02)
  • ubiquitous
    by Mcnicholas Natashia (2018-06-02)
  • zinc
    by Goudy Cline (2018-06-02)
  • ubiquitous
    by Disher Maribeth (2018-06-02)
  • quaint
    by Freyer Garrigan (2018-06-02)
  • wicked
    by Racquel Doloris (2018-06-02)
  • payment
    by Jolliff Brevard (2018-06-02)
  • absurd
    by Jiles Neal (2018-06-02)
  • economic
    by Cuomo Valencia (2018-06-02)
  • zippy
    by Freyer Esperanza (2018-06-02)
  • mint
    by Sumler Susana (2018-06-02)
  • hunt
    by Lacourse Brooks (2018-06-02)
  • train
    by Donovan Adela (2018-06-02)
  • lumpy
    by Carl Jiles (2018-06-02)
  • grab
    by Lawver Tressie (2018-06-02)
  • type
    by Bev Crista (2018-06-02)
  • stomach
    by Korn Matsuda (2018-06-02)
  • lumpy
    by Esterly Voltz (2018-06-02)
  • test
    by Hession Nickie (2018-06-02)
  • land
    by Cory Mae (2018-06-02)
  • doubt
    by Desrosier Cuomo (2018-06-03)
  • crowd
    by Cooley Korn (2018-06-03)
  • collect
    by Aquilino Atilano (2018-06-03)
  • unsightly
    by Keith Shanon (2018-06-03)
  • glow
    by Azar Demaris (2018-06-03)
  • wing
    by Mcquiston Nurse (2018-06-03)
  • land
    by Babette Aichele (2018-06-03)
  • rapid
    by Bryant Johnette (2018-06-03)
  • mist
    by Gisele Brevard (2018-06-03)
  • lumpy
    by Latricia Ruben (2018-06-03)
  • exclusive
    by Goudy Schechter (2018-06-03)
  • wind
    by Treva Korn (2018-06-03)
  • stove
    by Brumbaugh Gannon (2018-06-03)
  • object
    by Barnes Goold (2018-06-03)
  • zinc
    by Arlene Sumiko (2018-06-03)
  • shaggy
    by Rosalee Eyman (2018-06-03)
  • shaky
    by Nelia Synthia (2018-06-03)
  • land
    by Lawver Esperanza (2018-06-03)
  • shaky
    by Cooley Arlinda (2018-06-04)
  • bikes
    by Donald Carrera (2018-06-04)
  • cough
    by Millsaps Renwick (2018-06-04)
  • juicy
    by Cory Mcnicholas (2018-06-04)
  • wing
    by Earwood Arlene (2018-06-04)
  • sick
    by Jenelle Cataldo (2018-06-04)
  • shrug
    by Donovan Leonida (2018-06-04)
  • chalk
    by Natashia Luu (2018-06-04)
  • scene
    by Maclean Daphne (2018-06-04)
  • safe
    by Aichele Keva (2018-06-04)
  • faithful
    by Vernita Mantooth (2018-06-04)
  • cushion
    by Garrigan Nies (2018-06-04)
  • shrug
    by Chesser Benner (2018-06-04)
  • fabulous
    by Disher Tammi (2018-06-04)
  • train
    by Jiles Dolores (2018-06-04)
  • alert
    by Esterly Gigi (2018-06-04)
  • trashy
    by Sanjuana Stlouis (2018-06-04)
  • young
    by Grayce Maclean (2018-06-04)
  • title
    by Grisel Shofner (2018-06-04)
  • zippy
    by Neta Arlene (2018-06-04)
  • payment
    by Lando Stucker (2018-06-04)
  • train
    by Emanuel Jannette (2018-06-04)
  • mother
    by Lance Lehto (2018-06-04)
  • quaint
    by Emanuel Roxann (2018-06-04)
  • visit
    by Arlinda Jauregui (2018-06-04)
  • unsightly
    by Babette Louetta (2018-06-04)
  • title
    by Freyer Mitchel (2018-06-04)
  • yam
    by Kierstead Lawver (2018-06-04)
  • selective
    by Vanness Rosena (2018-06-04)
  • twist
    by Ruben Neta (2018-06-04)
  • guitar
    by Seegmiller Leonida (2018-06-04)
  • doubt
    by Tressa Nies (2018-06-04)
  • guitar
    by Keith Cataldo (2018-06-04)
  • zinc
    by Demaris Voltz (2018-06-04)
  • kittens
    by Shawnna Gigi (2018-06-04)
  • faithful
    by Jolliff Mae (2018-06-04)
  • crowd
    by Jauregui Vernita (2018-06-04)
  • alert
    by Star Jantz (2018-06-05)
  • analyse
    by Dolores Doloris (2018-06-05)
  • clam
    by Mitchell Vernita (2018-06-05)
  • analyse
    by Renea Wentzell (2018-06-05)
  • young
    by Wentzell Eyman (2018-06-05)
  • juicy
    by Andrade Shane (2018-06-05)
  • cushion
    by Stucker Freyer (2018-06-05)
  • bright
    by Delaine Grayce (2018-06-05)
  • lumpy
    by Brumbaugh Esteban (2018-06-05)
  • rapid
    by Schneiderman Tressa (2018-06-05)
  • land
    by Nickie Kris (2018-06-05)
  • cough
    by Louetta Benner (2018-06-05)
  • shaky
    by Ritchie Jennell (2018-06-05)
  • doubt
    by Synthia Cooley (2018-06-05)
  • hunt
    by Jolliff Freyer (2018-06-05)
  • future
    by Trapani Aquilino (2018-06-05)
  • bright
    by Terresa Maclean (2018-06-05)
  • clam
    by Cline Edington (2018-06-05)
  • decay
    by Shane Tressa (2018-06-05)
  • horrible
    by Cataldo Sumiko (2018-06-06)
  • cushion
    by Cesar Gannon (2018-06-06)
  • connection
    by Keith Esterly (2018-06-06)
  • jellyfish
    by Gannon Susana (2018-06-06)
  • juicy
    by Duong Gregoria (2018-06-06)
  • sky
    by Jolliff Tressie (2018-06-06)
  • cough
    by Alysa Gisele (2018-06-06)
  • economic
    by Johnette Kinnaird (2018-06-06)
  • juicy
    by Kirk Kris (2018-06-06)
  • quaint
    by Stucker Gigi (2018-06-06)
  • absurd
    by Allie Neal (2018-06-06)
  • juicy
    by Tressie Davenport (2018-06-06)
  • dolls
    by Stlouis Jantz (2018-06-06)
  • object
    by Kierstead Carl (2018-06-06)
  • quicksand
    by Adela Lehto (2018-06-06)
  • land
    by Roland Lemon (2018-06-06)
  • sky
    by Mantooth Babette (2018-06-06)
  • pick
    by Carl Adela (2018-06-06)
  • young
    by Terrazas Javier (2018-06-06)
  • disagree
    by Lezlie Mariko (2018-06-06)
  • shaggy
    by Lawver Aichele (2018-06-06)
  • stamp
    by Neta Neta (2018-06-07)
  • disapprove
    by Donald Avelina (2018-06-07)
  • fabulous
    by Shofner Daphne (2018-06-07)
  • wind
    by Jantz Gregoria (2018-06-07)
  • internal
    by Leonida Tusing (2018-06-07)
  • train
    by Donovan Daphne (2018-06-07)
  • yam
    by Arlene Maclean (2018-06-07)
  • spell
    by Dolores Goudy (2018-06-07)
  • spell
    by Freyer Racquel (2018-06-07)
  • clam
    by January Duong (2018-06-07)
  • twist
    by Nies Donovan (2018-06-07)
  • exclusive
    by Alysa Maclean (2018-06-07)
  • abaft
    by Lehto Hession (2018-06-07)
  • mother
    by Shanon Cuomo (2018-06-07)
  • lumpy
    by Dematteo Synthia (2018-06-07)
  • grade
    by Cline Kimble (2018-06-07)
  • guitar
    by Garrigan Mcquiston (2018-06-07)
  • obsequious
    by Esperanza Stucker (2018-06-07)
  • charming
    by Shira Krieger (2018-06-07)
  • many
    by Cory Keva (2018-06-07)
  • spell
    by Carl Vandermolen (2018-06-07)
  • doubt
    by Johnathan Jantz (2018-06-07)
  • title
    by Luu Rees (2018-06-07)
  • zinc
    by Kierstead Alysa (2018-06-07)
  • compete
    by Gannon Esperanza (2018-06-07)
  • wing
    by Goudy Seegmiller (2018-06-07)
  • abaft
    by Freyer Jantz (2018-06-07)
  • alert
    by Esteban Garrigan (2018-06-07)
  • decorous
    by Nurse Vernita (2018-06-07)
  • terrify
    by Earwood Seegmiller (2018-06-07)
  • decorous
    by Racquel Sanjuana (2018-06-07)
  • ubiquitous
    by Mitchel Azar (2018-06-08)
  • internal
    by Brumbaugh Alysa (2018-06-08)
  • type
    by Bird Tocco (2018-06-08)
  • abaft
    by Allie Roseline (2018-06-08)
  • pull
    by Mcquiston Sanjuana (2018-06-08)
  • decay
    by Disher Mantooth (2018-06-08)
  • cabbage
    by Mitchell Cyndy (2018-06-08)
  • difficult
    by Chesser Krieger (2018-06-08)
  • young
    by Jiles Mitchel (2018-06-08)
  • disagree
    by Gannon Arrieta (2018-06-08)
  • shaky
    by Trapani Leonida (2018-06-08)
  • test
    by Genoveva Shawnna (2018-06-08)
  • zinc
    by Shane Terrazas (2018-06-08)
  • lumpy
    by Seegmiller Trezza (2018-06-08)
  • type
    by Nurse Cooley (2018-06-08)
  • juicy
    by Carina Sumiko (2018-06-08)
  • type
    by Vanness Carl (2018-06-08)
  • title
    by Ritchie Jannette (2018-06-08)
  • stamp
    by Lance Maclean (2018-06-08)
  • way
    by Nurse Jantz (2018-06-08)
  • crowd
    by Neta Allie (2018-06-08)
  • shaky
    by Desrosier Keva (2018-06-08)
  • wind
    by Brumbaugh Roseline (2018-06-08)
  • analyse
    by Goold Jenelle (2018-06-08)
  • disapprove
    by Azar Tammi (2018-06-08)
  • absurd
    by Jauregui Norsworthy (2018-06-08)
  • jellyfish
    by Kiara Allyson (2018-06-08)
  • unsightly
    by Stucker Millsaps (2018-06-08)
  • trashy
    by Lance Doloris (2018-06-08)
  • twist
    by Mcquiston Edgar (2018-06-08)
  • drown
    by Fredda Lacourse (2018-06-08)
  • shivering
    by Nelia Jolliff (2018-06-08)
  • wing
    by Stanton Jannette (2018-06-08)
  • visit
    by Trezza Shanon (2018-06-08)
  • zinc
    by Cuomo Rees (2018-06-08)
  • exuberant
    by Azar Silber (2018-06-08)
  • many
    by Demaris Holley (2018-06-08)
  • terrify
    by Lucilla Gale (2018-06-08)
  • jellyfish
    by Azar Sadie (2018-06-08)
  • rapid
    by Gregoria Delaine (2018-06-08)
  • pull
    by Demaris Shanon (2018-06-08)
  • internal
    by Lynsey Seegmiller (2018-06-08)
  • exclusive
    by Willis Lehto (2018-06-08)
  • internal
    by Seegmiller Nitz (2018-06-08)
  • crowd
    by Carl Tressie (2018-06-08)
  • economic
    by Cline Mcnicholas (2018-06-08)
  • abstracted
    by Jiles Mitchel (2018-06-08)
  • wind
    by Siegal Ruland (2018-06-08)
  • difficult
    by Nitz Gisele (2018-06-08)
  • horrible
    by Schneiderman Schneiderman (2018-06-08)
  • glow
    by Esperanza Mcnicholas (2018-06-08)
  • drown
    by Cataldo Carina (2018-06-08)
  • pick
    by Cassi Brumbaugh (2018-06-08)
  • doubt
    by Lezlie Kilby (2018-06-08)
  • internal
    by Disher Delorse (2018-06-08)
  • object
    by Aichele Stucker (2018-06-08)
  • visit
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    by Trezza Brooks (2018-06-27)
  • young
    by Larsen Emanuel (2018-06-27)
  • bright
    by Carina Stlouis (2018-06-27)
  • quaint
    by Dung Bryant (2018-06-27)
  • faithful
    by Freyer Dolores (2018-06-27)
  • payment
    by Neta Freyer (2018-06-27)
  • dolls
    by Goold Mariko (2018-06-27)
  • coach
    by Shawnna Gisele (2018-06-27)
  • stingy
    by Janita Janita (2018-06-27)
  • selective
    by Mcnicholas Rosena (2018-06-27)
  • drain
    by Grayce Millsaps (2018-06-27)
  • ray
    by Nicholls Racquel (2018-06-28)
  • fall
    by Donovan Shofner (2018-06-28)
  • train
    by Edgar Mae (2018-06-28)
  • cabbage
    by Louetta Roseline (2018-06-28)
  • drain
    by Demaris Nickie (2018-06-28)
  • zinc
    by Jauregui Holley (2018-06-28)
  • safe
    by Ritchie Ladawn (2018-06-28)
  • object
    by Silber Holley (2018-06-28)
  • charming
    by Daphne Latricia (2018-06-28)
  • walk
    by Lehto Shawnna (2018-06-28)
  • stamp
    by Tressa Barnes (2018-06-28)
  • guitar
    by Vandermolen Ruben (2018-06-28)
  • sick
    by Keva Deno (2018-06-28)
  • ray
    by Arlene Sandridge (2018-06-28)
  • chalk
    by Hession Delaine (2018-06-28)
  • clean
    by Gale Ladawn (2018-06-28)
  • alert
    by Gisele Cyndy (2018-06-28)
  • helpless
    by Sumiko Nelia (2018-06-29)
  • future
    by Donovan Grisel (2018-06-29)
  • zippy
    by Johnette Demaris (2018-06-29)
  • zippy
    by Terrazas Kinnaird (2018-06-29)
  • drain
    by Bryant Atchley (2018-06-29)
  • relax
    by Jannette Mae (2018-06-29)
  • cough
    by Louetta Azar (2018-06-29)
  • analyse
    by Nurse Gisele (2018-06-29)
  • horrible
    by Schechter Destiny (2018-06-29)
  • absurd
    by Atchley Gannon (2018-06-29)
  • disagree
    by January Deno (2018-06-29)
  • glow
    by Tammi Avelina (2018-06-29)
  • bright
    by January Jennell (2018-06-29)
  • spell
    by Renwick Hession (2018-06-29)
  • dolls
    by Neta Mariko (2018-06-29)
  • horrible
    by Matsuda Maxima (2018-06-30)
  • stingy
    by Sumler Grisel (2018-06-30)
  • type
    by Cataldo Grayce (2018-06-30)
  • grin
    by Leonida Vance (2018-06-30)
  • selective
    by Emanuel Edington (2018-06-30)
  • bikes
    by Gannon Louetta (2018-06-30)
  • relax
    by Mitchel Star (2018-06-30)
  • land
    by Sadie Maclean (2018-06-30)
  • relax
    by Susana Neta (2018-06-30)
  • mist
    by January Andrade (2018-06-30)
  • train
    by Star Maclean (2018-06-30)
  • charming
    by Tocco Stlouis (2018-06-30)
  • mother
    by Hession Annamaria (2018-06-30)
  • drain
    by Delorse Crista (2018-06-30)
  • many
    by Mae Maribeth (2018-06-30)
  • clean
    by Mae Cassi (2018-06-30)
  • trashy
    by Esterly Kirk (2018-06-30)
  • wind
    by Neta Renea (2018-07-01)
  • zinc
    by Cataldo Carina (2018-07-01)
  • chalk
    by Demaris Davenport (2018-07-01)
  • innocent
    by Duong Shane (2018-07-01)
  • title
    by Goudy Esperanza (2018-07-01)
  • safe
    by Ruben Annamaria (2018-07-01)
  • guitar
    by Luu Wentzell (2018-07-01)
  • type
    by Gisele Valencia (2018-07-01)
  • bright
    by Synthia Bryant (2018-07-01)
  • walk
    by Vandermolen Tusing (2018-07-02)
  • ready
    by Mariko Star (2018-07-02)
  • relax
    by Aichele Schneiderman (2018-07-02)
  • future
    by Goudy Genoveva (2018-07-02)
  • kittens
    by Adela Sandridge (2018-07-02)
  • exclusive
    by Arlinda Chesser (2018-07-02)
  • mother
    by Roland Silber (2018-07-02)
  • exclusive
    by Synthia Disher (2018-07-02)
  • grade
    by Seegmiller Mariko (2018-07-02)
  • stingy
    by Andrade Lawver (2018-07-03)
  • object
    by Racquel Gregoria (2018-07-03)
  • stove
    by Terrazas Allyson (2018-07-03)
  • stove
    by Ruben Kiara (2018-07-03)
  • cabbage
    by Terrazas Shane (2018-07-03)
  • sick
    by Ruben Kathy (2018-07-03)
  • collect
    by Kiara Star (2018-07-03)
  • twist
    by Alysa Maclean (2018-07-03)
  • Good job
    by Canh Dep Trai (2018-07-03)
  • pull
    by Jennell Gisele (2018-07-03)
  • fall
    by Babette Esteban (2018-07-03)
  • kittens
    by Mariko Jiles (2018-07-03)
  • shaky
    by Mantooth Trapani (2018-07-03)
  • absurd
    by Fredda Nurse (2018-07-03)
  • hair
    by Duong Rosena (2018-07-03)
  • zinc
    by Esperanza Treva (2018-07-03)
  • horrible
    by Goold Aichele (2018-07-03)
  • wicked
    by Cuomo Lehto (2018-07-04)
  • economic
    by Wentzell Duong (2018-07-04)
  • jellyfish
    by Tusing Maribeth (2018-07-04)
  • economic
    by Willis Barnes (2018-07-04)
  • rapid
    by Groman Hession (2018-07-04)
  • relax
    by Davenport Brevard (2018-07-04)
  • twist
    by Holley Maxima (2018-07-04)
  • shivering
    by Shawnna Alysa (2018-07-04)
  • fabulous
    by Natashia Luu (2018-07-04)
  • bikes
    by Cyndy Alysa (2018-07-04)
  • abaft
    by Sumiko Korn (2018-07-04)
  • compete
    by Alysa Bird (2018-07-04)
  • shaggy
    by Donovan Maribeth (2018-07-04)
  • decay
    by Lynsey Duong (2018-07-04)
  • title
    by Valencia Gigi (2018-07-04)
  • shaky
    by Genoveva Sadie (2018-07-04)
  • grade
    by Goold Hession (2018-07-04)
  • fabulous
    by Vance Vance (2018-07-04)
  • wicked
    by Silber Vance (2018-07-05)
  • alert
    by Rees Johnette (2018-07-05)
  • safe
    by Kiara Maxima (2018-07-05)
  • disagree
    by Brooks Delorse (2018-07-05)
  • collect
    by Renea Bryant (2018-07-05)
  • mint
    by January Sadie (2018-07-05)
  • selective
    by Nitz Freyer (2018-07-05)
  • zippy
    by Schechter Stanton (2018-07-05)
  • many
    by Johnathan Freyer (2018-07-06)
  • scene
    by Lacourse Vandermolen (2018-07-06)
  • scene
    by Gale Kirk (2018-07-06)
  • innocent
    by Norsworthy Brumbaugh (2018-07-06)
  • selective
    by Lehto Lasonya (2018-07-06)
  • economic
    by Kirk Louetta (2018-07-06)
  • ready
    by Avelina Sumler (2018-07-06)
  • internal
    by Vernita Stucker (2018-07-06)
  • crowd
    by Lezlie Kathy (2018-07-06)
  • stomach
    by Brevard Jenelle (2018-07-06)
  • yam
    by Benner Rosena (2018-07-06)
  • alert
    by Terrazas Trapani (2018-07-06)
  • internal
    by Lynsey Natashia (2018-07-06)
  • ubiquitous
    by Rees Vance (2018-07-06)
  • rapid
    by Seegmiller Esperanza (2018-07-06)
  • juicy
    by Arlinda Lawver (2018-07-06)
  • yam
    by Rosalee Shawnna (2018-07-07)
  • relax
    by Gisele Benner (2018-07-07)
  • clean
    by Andrade Kinnaird (2018-07-07)
  • abstracted
    by Sumiko Edington (2018-07-07)
  • stamp
    by Esperanza Gregoria (2018-07-07)
  • jellyfish
    by Brevard Nickie (2018-07-07)
  • pull
    by Lasonya Lemon (2018-07-07)
  • scene
    by Kierstead Nitz (2018-07-07)
  • spell
    by Vandermolen Shane (2018-07-07)
  • train
    by Schneiderman Keith (2018-07-07)
  • charming
    by Cooley Ruland (2018-07-07)
  • escape
    by Dolores Carl (2018-07-07)
  • drain
    by Avelina Shofner (2018-07-07)
  • ready
    by Genoveva Azar (2018-07-07)
  • pick
    by Keva Andrade (2018-07-07)
  • obsequious
    by Tusing Tusing (2018-07-07)
  • crowd
    by Daphne Chesser (2018-07-07)
  • coach
    by Annamaria Cyndy (2018-07-07)
  • grin
    by Davenport Adell (2018-07-07)
  • kittens
    by Crista Esterly (2018-07-07)
  • juicy
    by Roseline January (2018-07-07)
  • disagree
    by Kimble Terrazas (2018-07-07)
  • wind
    by Ruland Tusing (2018-07-07)
  • bright
    by Goudy Alysa (2018-07-07)
  • drain
    by Nitz Allie (2018-07-07)
  • pick
    by Dung Holley (2018-07-08)
  • hair
    by Hession Goudy (2018-07-08)
  • cabbage
    by Seegmiller Cesar (2018-07-08)
  • safe
    by Benner Delorse (2018-07-08)
  • ready
    by Maxima Gisele (2018-07-08)
  • grade
    by Goold Lezlie (2018-07-08)
  • abstracted
    by Jenelle Star (2018-07-08)
  • train
    by Leonida Cuomo (2018-07-08)
  • dolls
    by Lasonya Esperanza (2018-07-08)
  • relax
    by Racquel Bev (2018-07-08)
  • disapprove
    by Schneiderman Voltz (2018-07-08)
  • clean
    by Lucilla Jennell (2018-07-08)
  • innocent
    by Ruland Krieger (2018-07-08)
  • test
    by Benner Star (2018-07-09)
  • charming
    by Janita Bev (2018-07-09)
  • title
    by Trapani Carina (2018-07-09)
  • wind
    by Rusk Alysa (2018-07-09)
  • fall
    by Jannette Mcquiston (2018-07-09)
  • fabulous
    by Cataldo Janita (2018-07-09)
  • yam
    by Grisel Babette (2018-07-09)
  • helpless
    by Johnette Krieger (2018-07-09)
  • chalk
    by Delorse Brumbaugh (2018-07-09)
  • faithful
    by Neal Atilano (2018-07-09)
  • relax
    by Duong Gale (2018-07-09)
  • connection
    by Tressie Gannon (2018-07-09)
  • obsequious
    by Nurse Holley (2018-07-09)
  • dolls
    by Sanjuana Brooke (2018-07-09)
  • shivering
    by Davenport Star (2018-07-09)
  • grade
    by Bird Millsaps (2018-07-09)
  • shaggy
    by Daphne Atilano (2018-07-09)
  • jellyfish
    by Janita Javier (2018-07-09)
  • hunt
    by Sanjuana Kris (2018-07-09)
  • future
    by Eyman Dolores (2018-07-09)
  • stomach
    by Nicholls Shofner (2018-07-09)
  • hunt
    by Neta Trezza (2018-07-09)
  • decorous
    by Aquilino Tressa (2018-07-10)
  • terrify
    by Ritchie Roxann (2018-07-10)
  • fall
    by Gisele Aquilino (2018-07-10)
  • unsightly
    by Silber Delorse (2018-07-10)
  • hair
    by Johnette Star (2018-07-10)
  • grade
    by Latricia Kimble (2018-07-10)
  • innocent
    by Tressie Babette (2018-07-10)
  • difficult
    by Kris Lacourse (2018-07-10)
  • terrify
    by Jennell Crista (2018-07-10)
  • trashy
    by Sadie Eyman (2018-07-10)
  • type
    by Stanton Keith (2018-07-10)
  • type
    by Arrieta Lynsey (2018-07-10)
  • test
    by Stlouis Atilano (2018-07-10)
  • chalk
    by Allie Cline (2018-07-10)
  • dolls
    by Lehto Mae (2018-07-10)
  • grade
    by Tressa Barnes (2018-07-11)
  • coach
    by Allie Kiara (2018-07-11)
  • ubiquitous
    by Lando Maxima (2018-07-11)
  • wind
    by Ruben Genoveva (2018-07-11)
  • disagree
    by Gigi Gisele (2018-07-11)
  • obsequious
    by Emanuel Allie (2018-07-11)
  • exclusive
    by Edgar Cory (2018-07-11)
  • clean
    by Jannette Andrade (2018-07-11)
  • economic
    by Lance Synthia (2018-07-11)
  • yam
    by Rosalee Jolliff (2018-07-11)
  • zinc
    by Lezlie Rosena (2018-07-11)
  • cough
    by Carrera Allyson (2018-07-11)
  • connection
    by Mae Carina (2018-07-11)
  • stingy
    by Esperanza Nurse (2018-07-12)
  • many
    by Shanon Nelia (2018-07-12)
  • unsightly
    by Cory Vandermolen (2018-07-12)
  • exclusive
    by Deno Mitchel (2018-07-12)
  • grade
    by Nelia Cesar (2018-07-12)
  • disapprove
    by Renwick Tocco (2018-07-12)
  • difficult
    by Lance Brevard (2018-07-12)
  • sky
    by Chesser Carina (2018-07-13)
  • scene
    by Desrosier Edington (2018-07-13)
  • shaggy
    by Silber Lippard (2018-07-13)
  • stingy
    by Synthia Schechter (2018-07-13)
  • bikes
    by Vernita Lemon (2018-07-13)
  • walk
    by Carrera Willis (2018-07-13)
  • drain
    by Maclean Vance (2018-07-13)
  • type
    by Edgar Rusk (2018-07-13)
  • unsightly
    by Krieger Genoveva (2018-07-13)
  • quaint
    by Duong Luu (2018-07-13)
  • train
    by Maclean Allie (2018-07-13)
  • object
    by Maxima Shawnna (2018-07-13)
  • shaky
    by Gannon Maribeth (2018-07-13)
  • yam
    by Tusing Dematteo (2018-07-13)
  • object
    by Lucilla Keva (2018-07-13)
  • ray
    by Doloris Racquel (2018-07-13)
  • absurd
    by Daphne Schechter (2018-07-13)
  • analyse
    by Duong Emanuel (2018-07-13)
  • drown
    by Deno Silber (2018-07-13)
  • connection
    by Vance Atilano (2018-07-13)
  • sky
    by Esperanza Tressie (2018-07-14)
  • hunt
    by Jenelle Treva (2018-07-15)
  • unsightly
    by Brevard Alysa (2018-07-16)
  • horrible
    by Bird Benner (2018-07-16)
  • disagree
    by Maribeth Alysa (2018-07-17)
  • many
    by Maribeth Demaris (2018-07-17)
  • many
    by Tressie Neal (2018-07-17)
  • rapid
    by Norsworthy Ruben (2018-07-17)
  • twist
    by Sumiko Chesser (2018-07-17)
  • disapprove
    by Delorse Delaine (2018-07-18)
  • clean
    by Nitz Garrigan (2018-07-18)
  • bright
    by Renea Destiny (2018-07-19)
  • internal
    by Andrade Dematteo (2018-07-19)
  • abstracted
    by Jannette Tressa (2018-07-19)
  • stove
    by Emanuel Sumiko (2018-07-19)
  • chalk
    by Deno Sadie (2018-07-19)
  • train
    by Andrade Jauregui (2018-07-19)
  • lumpy
    by Gale Millsaps (2018-07-20)
  • absurd
    by Goudy Alysa (2018-07-20)
  • horrible
    by Tressa Gannon (2018-07-20)
  • wicked
    by Jauregui Tressie (2018-07-20)
  • mint
    by Doloris Renea (2018-07-20)
  • zinc
    by Aichele Mariko (2018-07-21)
  • dolls
    by Lacourse Demaris (2018-07-21)
  • helpless
    by Emanuel Tressie (2018-07-21)
  • clean
    by Crista Mitchell (2018-07-22)
  • bikes
    by Barnes Kris (2018-07-22)
  • stingy
    by Barnes Deno (2018-07-23)
  • twist
    by Star Racquel (2018-07-23)
  • hunt
    by Cassi Vernita (2018-07-23)
  • fabulous
    by Gisele Schechter (2018-07-23)
  • clam
    by Gale Eyman (2018-07-23)
  • trashy
    by Adela Jauregui (2018-07-23)
  • trashy
    by Synthia Carl (2018-07-23)
  • pull
    by Louetta Matsuda (2018-07-24)
  • sky
    by Johnathan Alysa (2018-07-24)
  • young
    by Shane Kimble (2018-07-24)
  • train
    by Cyndy Daphne (2018-07-24)
  • pick
    by Nicholls Dolores (2018-07-24)
  • many
    by Earwood Stucker (2018-07-24)
  • visit
    by Larsen Azar (2018-07-24)
  • type
    by Trapani Shofner (2018-07-24)
  • selective
    by Maclean Silber (2018-07-24)
  • rapid
    by Korn Rosalee (2018-07-24)
  • bright
    by Allyson Bird (2018-07-24)
  • analyse
    by Grisel Davenport (2018-07-24)
  • helpless
    by Racquel Eyman (2018-07-24)
  • selective
    by Lucilla Brumbaugh (2018-07-24)
  • cough
    by Dematteo Keith (2018-07-24)
  • relax
    by Andrade Mcquiston (2018-07-24)
  • ray
    by Nurse Hession (2018-07-24)
  • grin
    by Nelia Star (2018-07-24)
  • grab
    by Redus Latricia (2018-07-24)
  • walk
    by Rosalee Nies (2018-07-24)
  • guitar
    by Edington Davenport (2018-07-24)
  • chalk
    by Deno Dolores (2018-07-24)
  • terrify
    by Shanon Roseline (2018-07-24)
  • shaggy
    by Arrieta Carl (2018-07-24)
  • jellyfish
    by Barnes Sadie (2018-07-24)
  • coach
    by Dung Roseline (2018-07-25)
  • ready
    by Cyndy Tocco (2018-07-25)
  • wind
    by Sumler Kierstead (2018-07-25)
  • drown
    by Gisele Andrade (2018-07-25)
  • fabulous
    by Latricia Sanjuana (2018-07-25)
  • hair
    by Brevard Keith (2018-07-25)
  • pick
    by Roland Carrera (2018-07-25)
  • twist
    by Carrera Groman (2018-07-25)
  • type
    by Neal Sadie (2018-07-25)
  • lumpy
    by Doloris Valencia (2018-07-25)
  • sky
    by Willis Groman (2018-07-25)
  • mother
    by Lasonya Korn (2018-07-25)
  • decay
    by Donovan Sanjuana (2018-07-25)
  • quicksand
    by Johnette Kris (2018-07-25)
  • shaggy
    by Millsaps Cassi (2018-07-25)
  • stove
    by Lippard Mcquiston (2018-07-25)
  • fabulous
    by Tammi Korn (2018-07-25)
  • shaggy
    by Tressie Bryant (2018-07-25)
  • shaky
    by Lasonya Carina (2018-07-25)
  • ray
    by Louetta Nelia (2018-07-25)
  • sky
    by Lippard Kirk (2018-07-25)
  • bikes
    by Redus Racquel (2018-07-25)
  • exuberant
    by Voltz Fredda (2018-07-25)
  • quicksand
    by Dolores Sumiko (2018-07-25)
  • shaky
    by Emanuel Kimble (2018-07-26)
  • hunt
    by Davenport Vernita (2018-07-26)
  • thank
    by dung mai (2018-07-26)
  • zinc
    by Donovan Lucilla (2018-07-26)
  • zinc
    by Crista Lezlie (2018-07-26)
  • charming
    by Nelia Kathy (2018-07-26)
  • coach
    by Vernita Earwood (2018-07-26)
  • ray
    by Terresa Holley (2018-07-26)
  • internal
    by Duong Lawver (2018-07-26)
  • mist
    by Jolliff Eyman (2018-07-26)
  • abstracted
    by Aichele Desrosier (2018-07-26)
  • trashy
    by Cyndy Terrazas (2018-07-26)
  • mint
    by Atilano Vanness (2018-07-26)
  • many
    by Dung Siegal (2018-07-26)
  • terrify
    by Vanness Synthia (2018-07-26)
  • disagree
    by Star Neal (2018-07-26)
  • future
    by Brumbaugh Star (2018-07-26)
  • crowd
    by Keith Cyndy (2018-07-27)
  • future
    by Cassi Bev (2018-07-27)
  • escape
    by Ladawn Korn (2018-07-27)
  • cough
    by Treva Sumler (2018-07-27)
  • visit
    by Cataldo Lasonya (2018-07-27)
  • visit
    by Jantz Daphne (2018-07-27)
  • abstracted
    by Keva Mcquiston (2018-07-27)
  • sky
    by Lasonya Bryant (2018-07-27)
  • quicksand
    by Mcnicholas Maxima (2018-07-27)
  • jellyfish
    by Wentzell Gannon (2018-07-27)
  • escape
    by Kierstead Esteban (2018-07-27)
  • sick
    by Nelia Jantz (2018-07-28)
  • alert
    by Cooley Siegal (2018-07-28)
  • decay
    by Trapani Jannette (2018-07-28)
  • stamp
    by Earwood Mantooth (2018-07-28)
  • guitar
    by Maxima Vance (2018-07-28)
  • grade
    by Chesser Bev (2018-07-28)
  • hunt
    by Grayce Aichele (2018-07-28)
  • many
    by Tressie Sandridge (2018-07-28)
  • grin
    by Ritchie Trapani (2018-07-29)
  • abstracted
    by Cline Jantz (2018-07-29)
  • many
    by Maclean Rosena (2018-07-29)
  • unsightly
    by Chesser Ritchie (2018-07-29)
  • wing
    by Kilby Cesar (2018-07-29)
  • cabbage
    by Mcnicholas Gregoria (2018-07-29)
  • difficult
    by Tressie Javier (2018-07-29)
  • decay
    by Rosena Garrigan (2018-07-29)
  • quicksand
    by Kinnaird Carl (2018-07-29)
  • helpless
    by Benner Dolores (2018-07-30)
  • kittens
    by Ruben Edington (2018-07-31)
  • shivering
    by Doloris Ladawn (2018-07-31)
  • selective
    by Gregoria Delaine (2018-07-31)
  • abstracted
    by Renea Sandridge (2018-08-02)
  • kittens
    by Seegmiller Arrieta (2018-08-02)
  • safe
    by Maclean Kris (2018-08-02)
  • O Que Fazer Para Cortar O Cabelo Quebrado
    by Sarah Duarte (2018-08-03)
  • hunt
    by Ladawn Leonida (2018-08-03)
  • land
    by Jantz Lacourse (2018-08-03)
  • zippy
    by Lippard Mitchell (2018-08-03)
  • grin
    by Allie Schechter (2018-08-03)
  • شركة تنظيف فلل بالرياض
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  • hunt
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