The war against cancer: Suicide gene therapy
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The National Cancer Institute and the American Cancer Society announced that 1.6 million new cancer cases are projected to occur in the USA in 2016. One of the most innovative approaches against cancer is suicide gene therapy, in which suicide-inducing transgenes are introduced into cancer cells. When cancer treatments target the total elimination of tumor cells, there will be no side effects for normal cells. Cancer tissues are targeted through various targeted transport methods, followed by tissue-specific enzymes converting a systemically suitable prodrug into an active drug in the tumor. Suicidal genes are delivered by transporters, such as viral and non-viral vectors, into cancer cells. Suicide gene therapeutic strategies currently pursued are herpes simplex virus thymidine kinase gene with prodrug ganciclovir, cytosine deaminase gene, carboxyl esterase/irinotecan, varicella zoster virus thymidine kinase/6-methoxypurine arabinonucleoside, nitroreductase Nfsb/5-(aziridin-1-yl)-2,4-dinitrobenzamide, carboxypeptidase G2/4-[(2-chloroethyl)(2- mesyloxyethyl)amino]benzoyl-L-glutamic acid, cytochrome p450-isofosfamide, and cytochrome p450-cyclophosphamide. The goal of this review is to summarize the different suicide gene systems and gene delivery vectors addressed to cancer cells, with a particular emphasis on recently developed systems. Finally, we briefly describe the advantageous clinical applications and potential side effects of suicide gene therapy.
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DOI: http://dx.doi.org/10.18282/amor.v2.i3.103
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by Grisel Brooks (2018-05-25)
by Keva Carl (2018-05-25)
by Stanton Latricia (2018-05-25)
by Janita Sumler (2018-05-25)
by Genoveva Natashia (2018-05-25)
by Keva Emanuel (2018-05-25)
by Nurse Lippard (2018-05-25)
by Jannette Mcnicholas (2018-05-25)
by Ritchie Chesser (2018-05-25)
by Ritchie Valencia (2018-05-25)
by Kierstead Alysa (2018-05-25)
by Jauregui Mitchell (2018-05-25)
by Renwick Kinnaird (2018-05-25)
by Gannon Keva (2018-05-25)
by Kirk Grisel (2018-05-25)
by Esperanza Edgar (2018-05-25)
by Annamaria Grayce (2018-05-25)
by Nickie Brumbaugh (2018-05-26)
by Brevard Eyman (2018-05-26)
by Star Siegal (2018-05-26)
by Willis Keva (2018-05-26)
by Jannette Maxima (2018-05-26)
by Gale Treva (2018-05-26)
by Benner Neal (2018-05-26)
by Luu Jiles (2018-05-26)
by Nelia Ladawn (2018-05-26)
by Johnette Mariko (2018-05-26)
by Earwood Latricia (2018-05-26)
by Gisele Stlouis (2018-05-26)
by Donald Disher (2018-05-26)
by Daphne Bev (2018-05-26)
by Gannon Mcnicholas (2018-05-26)
by Nies Jiles (2018-05-26)
by Keith Neal (2018-05-26)
by Gregoria Sandridge (2018-05-26)
by Earwood Racquel (2018-05-26)
by Shane Kris (2018-05-27)
by Siegal Maribeth (2018-05-27)
by Lasonya Rosena (2018-05-27)
by Enciso Terrazas (2018-05-27)
by Shane Millsaps (2018-05-27)
by Cory Babette (2018-05-27)
by Javier Sanjuana (2018-05-27)
by Holley January (2018-05-27)
by Vance Vance (2018-05-27)
by Andrade Cooley (2018-05-27)
by Larsen Cooley (2018-05-27)
by Mariko Esperanza (2018-05-27)
by Vance Redus (2018-05-27)
by Brooks Goold (2018-05-27)
by Arrieta Azar (2018-05-27)
by Ruben Brooke (2018-05-28)
by Kris Jauregui (2018-05-28)
by Vance Esterly (2018-05-28)
by Willis Dolores (2018-05-28)
by Kris Tressie (2018-05-28)
by Nelia Gregoria (2018-05-28)
by Luu Star (2018-05-28)
by Matsuda Earwood (2018-05-28)
by Cuomo Carrera (2018-05-28)
by Susana Shofner (2018-05-28)
by Avelina Annamaria (2018-05-28)
by Fredda Lacourse (2018-05-28)
by Earwood Sumler (2018-05-28)
by Mantooth Latricia (2018-05-28)
by Trezza Delorse (2018-05-28)
by Brooke Silber (2018-05-28)
by Davenport Roxann (2018-05-28)
by Vance Cesar (2018-05-28)
by Rees Sadie (2018-05-28)
by Deno Wentzell (2018-05-28)
by Esperanza Lippard (2018-05-28)
by Lando Rosena (2018-05-28)
by Lucilla Lynsey (2018-05-28)
by Bev Carina (2018-05-29)
by Rusk Adela (2018-05-29)
by Javier Sadie (2018-05-29)
by Mcnicholas Shofner (2018-05-29)
by Bryant Brooks (2018-05-29)
by Jiles Benner (2018-05-29)
by Neal Natashia (2018-05-29)
by Atchley Bev (2018-05-29)
by Benner Sanjuana (2018-05-29)
by Nicholls Holley (2018-05-29)
by Treva Treva (2018-05-29)
by Allie Freyer (2018-05-29)
by Fredda Disher (2018-05-29)
by Larsen Renwick (2018-05-29)
by Kimble Ruland (2018-05-29)
by Lando Nurse (2018-05-29)
by Garrigan Dolores (2018-05-29)
by Babette Kierstead (2018-05-29)
by Alysa Goold (2018-05-30)
by Grayce Bryant (2018-05-30)
by Schneiderman January (2018-05-30)
by Davenport Lance (2018-05-30)
by Esterly Mantooth (2018-05-30)
by Renea Allie (2018-05-30)
by Shanon Norsworthy (2018-05-30)
by Racquel Leonida (2018-05-30)
by Millsaps Lehto (2018-05-30)
by Rosena Jenelle (2018-05-30)
by Sanjuana Roland (2018-05-30)
by Valencia Desrosier (2018-05-30)
by Crista Lezlie (2018-05-30)
by Shofner Mitchel (2018-05-30)
by Kathy Lacourse (2018-05-30)
by Babette Dung (2018-05-30)
by Brooke Fredda (2018-05-30)
by Aquilino Luu (2018-05-30)
by Siegal Mcnicholas (2018-05-30)
by Azar Brumbaugh (2018-05-31)
by Vance Brumbaugh (2018-05-31)
by Kimble Shira (2018-05-31)
by Delaine Bryant (2018-05-31)
by Schneiderman Mantooth (2018-05-31)
by Trezza Treva (2018-05-31)
by Millsaps Kirk (2018-05-31)
by Larsen Star (2018-05-31)
by Gannon Louetta (2018-05-31)
by Eyman Arlinda (2018-05-31)
by Gigi Dolores (2018-05-31)
by Dematteo Goold (2018-05-31)
by Lemon Lynsey (2018-05-31)
by Kierstead Desrosier (2018-06-01)
by Sumler Larsen (2018-06-01)
by Alysa Silber (2018-06-01)
by Freyer Rosena (2018-06-01)
by Delorse Mitchel (2018-06-01)
by Eyman Eyman (2018-06-01)
by Schneiderman Stlouis (2018-06-01)
by Arrieta Lance (2018-06-01)
by Sandridge Emanuel (2018-06-01)
by Kimble Tocco (2018-06-01)
by Gigi Star (2018-06-01)
by Dung Livers (2018-06-01)
by Racquel Lacourse (2018-06-01)
by Freyer Destiny (2018-06-01)
by Vanness Shawnna (2018-06-01)
by Treva Shanon (2018-06-01)
by Valencia Valencia (2018-06-02)
by Lynsey Arlinda (2018-06-02)
by Lippard Brooke (2018-06-02)
by Arrieta Lasonya (2018-06-02)
by Earwood Lacourse (2018-06-02)
by Tressie Gigi (2018-06-02)
by Schechter Bird (2018-06-02)
by Grayce Avelina (2018-06-02)
by Lasonya Kilby (2018-06-02)
by Roxann Nurse (2018-06-02)
by Delaine Mae (2018-06-02)
by Valencia Duong (2018-06-02)
by Nicholls Lucilla (2018-06-02)
by Roxann Disher (2018-06-02)
by Dematteo Davenport (2018-06-02)
by Kris Silber (2018-06-02)
by Mcnicholas Natashia (2018-06-02)
by Goudy Cline (2018-06-02)
by Disher Maribeth (2018-06-02)
by Freyer Garrigan (2018-06-02)
by Racquel Doloris (2018-06-02)
by Jolliff Brevard (2018-06-02)
by Jiles Neal (2018-06-02)
by Cuomo Valencia (2018-06-02)
by Freyer Esperanza (2018-06-02)
by Sumler Susana (2018-06-02)
by Lacourse Brooks (2018-06-02)
by Donovan Adela (2018-06-02)
by Carl Jiles (2018-06-02)
by Lawver Tressie (2018-06-02)
by Bev Crista (2018-06-02)
by Korn Matsuda (2018-06-02)
by Esterly Voltz (2018-06-02)
by Hession Nickie (2018-06-02)
by Cory Mae (2018-06-02)
by Desrosier Cuomo (2018-06-03)
by Cooley Korn (2018-06-03)
by Aquilino Atilano (2018-06-03)
by Keith Shanon (2018-06-03)
by Azar Demaris (2018-06-03)
by Mcquiston Nurse (2018-06-03)
by Babette Aichele (2018-06-03)
by Bryant Johnette (2018-06-03)
by Gisele Brevard (2018-06-03)
by Latricia Ruben (2018-06-03)
by Goudy Schechter (2018-06-03)
by Treva Korn (2018-06-03)
by Brumbaugh Gannon (2018-06-03)
by Barnes Goold (2018-06-03)
by Arlene Sumiko (2018-06-03)
by Rosalee Eyman (2018-06-03)
by Nelia Synthia (2018-06-03)
by Lawver Esperanza (2018-06-03)
by Cooley Arlinda (2018-06-04)
by Donald Carrera (2018-06-04)
by Millsaps Renwick (2018-06-04)
by Cory Mcnicholas (2018-06-04)
by Earwood Arlene (2018-06-04)
by Jenelle Cataldo (2018-06-04)
by Donovan Leonida (2018-06-04)
by Natashia Luu (2018-06-04)
by Maclean Daphne (2018-06-04)
by Aichele Keva (2018-06-04)
by Vernita Mantooth (2018-06-04)
by Garrigan Nies (2018-06-04)
by Chesser Benner (2018-06-04)
by Disher Tammi (2018-06-04)
by Jiles Dolores (2018-06-04)
by Esterly Gigi (2018-06-04)
by Sanjuana Stlouis (2018-06-04)
by Grayce Maclean (2018-06-04)
by Grisel Shofner (2018-06-04)
by Neta Arlene (2018-06-04)
by Lando Stucker (2018-06-04)
by Emanuel Jannette (2018-06-04)
by Lance Lehto (2018-06-04)
by Emanuel Roxann (2018-06-04)
by Arlinda Jauregui (2018-06-04)
by Babette Louetta (2018-06-04)
by Freyer Mitchel (2018-06-04)
by Kierstead Lawver (2018-06-04)
by Vanness Rosena (2018-06-04)
by Ruben Neta (2018-06-04)
by Seegmiller Leonida (2018-06-04)
by Tressa Nies (2018-06-04)
by Keith Cataldo (2018-06-04)
by Demaris Voltz (2018-06-04)
by Shawnna Gigi (2018-06-04)
by Jolliff Mae (2018-06-04)
by Jauregui Vernita (2018-06-04)
by Star Jantz (2018-06-05)
by Dolores Doloris (2018-06-05)
by Mitchell Vernita (2018-06-05)
by Renea Wentzell (2018-06-05)
by Wentzell Eyman (2018-06-05)
by Andrade Shane (2018-06-05)
by Stucker Freyer (2018-06-05)
by Delaine Grayce (2018-06-05)
by Brumbaugh Esteban (2018-06-05)
by Schneiderman Tressa (2018-06-05)
by Nickie Kris (2018-06-05)
by Louetta Benner (2018-06-05)
by Ritchie Jennell (2018-06-05)
by Synthia Cooley (2018-06-05)
by Jolliff Freyer (2018-06-05)
by Trapani Aquilino (2018-06-05)
by Terresa Maclean (2018-06-05)
by Cline Edington (2018-06-05)
by Shane Tressa (2018-06-05)
by Cataldo Sumiko (2018-06-06)
by Cesar Gannon (2018-06-06)
by Keith Esterly (2018-06-06)
by Gannon Susana (2018-06-06)
by Duong Gregoria (2018-06-06)
by Jolliff Tressie (2018-06-06)
by Alysa Gisele (2018-06-06)
by Johnette Kinnaird (2018-06-06)
by Kirk Kris (2018-06-06)
by Stucker Gigi (2018-06-06)
by Allie Neal (2018-06-06)
by Tressie Davenport (2018-06-06)
by Stlouis Jantz (2018-06-06)
by Kierstead Carl (2018-06-06)
by Adela Lehto (2018-06-06)
by Roland Lemon (2018-06-06)
by Mantooth Babette (2018-06-06)
by Carl Adela (2018-06-06)
by Terrazas Javier (2018-06-06)
by Lezlie Mariko (2018-06-06)
by Lawver Aichele (2018-06-06)
by Neta Neta (2018-06-07)
by Donald Avelina (2018-06-07)
by Shofner Daphne (2018-06-07)
by Jantz Gregoria (2018-06-07)
by Leonida Tusing (2018-06-07)
by Donovan Daphne (2018-06-07)
by Arlene Maclean (2018-06-07)
by Dolores Goudy (2018-06-07)
by Freyer Racquel (2018-06-07)
by January Duong (2018-06-07)
by Nies Donovan (2018-06-07)
by Alysa Maclean (2018-06-07)
by Lehto Hession (2018-06-07)
by Shanon Cuomo (2018-06-07)
by Dematteo Synthia (2018-06-07)
by Cline Kimble (2018-06-07)
by Garrigan Mcquiston (2018-06-07)
by Esperanza Stucker (2018-06-07)
by Shira Krieger (2018-06-07)
by Cory Keva (2018-06-07)
by Carl Vandermolen (2018-06-07)
by Johnathan Jantz (2018-06-07)
by Luu Rees (2018-06-07)
by Kierstead Alysa (2018-06-07)
by Gannon Esperanza (2018-06-07)
by Goudy Seegmiller (2018-06-07)
by Freyer Jantz (2018-06-07)
by Esteban Garrigan (2018-06-07)
by Nurse Vernita (2018-06-07)
by Earwood Seegmiller (2018-06-07)
by Racquel Sanjuana (2018-06-07)
by Mitchel Azar (2018-06-08)
by Brumbaugh Alysa (2018-06-08)
by Bird Tocco (2018-06-08)
by Allie Roseline (2018-06-08)
by Mcquiston Sanjuana (2018-06-08)
by Disher Mantooth (2018-06-08)
by Mitchell Cyndy (2018-06-08)
by Chesser Krieger (2018-06-08)
by Jiles Mitchel (2018-06-08)
by Gannon Arrieta (2018-06-08)
by Trapani Leonida (2018-06-08)
by Genoveva Shawnna (2018-06-08)
by Shane Terrazas (2018-06-08)
by Seegmiller Trezza (2018-06-08)
by Nurse Cooley (2018-06-08)
by Carina Sumiko (2018-06-08)
by Vanness Carl (2018-06-08)
by Ritchie Jannette (2018-06-08)
by Lance Maclean (2018-06-08)
by Nurse Jantz (2018-06-08)
by Neta Allie (2018-06-08)
by Desrosier Keva (2018-06-08)
by Brumbaugh Roseline (2018-06-08)
by Goold Jenelle (2018-06-08)
by Azar Tammi (2018-06-08)
by Jauregui Norsworthy (2018-06-08)
by Kiara Allyson (2018-06-08)
by Stucker Millsaps (2018-06-08)
by Lance Doloris (2018-06-08)
by Mcquiston Edgar (2018-06-08)
by Fredda Lacourse (2018-06-08)
by Nelia Jolliff (2018-06-08)
by Stanton Jannette (2018-06-08)
by Trezza Shanon (2018-06-08)
by Cuomo Rees (2018-06-08)
by Azar Silber (2018-06-08)
by Demaris Holley (2018-06-08)
by Lucilla Gale (2018-06-08)
by Azar Sadie (2018-06-08)
by Gregoria Delaine (2018-06-08)
by Demaris Shanon (2018-06-08)
by Lynsey Seegmiller (2018-06-08)
by Willis Lehto (2018-06-08)
by Seegmiller Nitz (2018-06-08)
by Carl Tressie (2018-06-08)
by Cline Mcnicholas (2018-06-08)
by Jiles Mitchel (2018-06-08)
by Siegal Ruland (2018-06-08)
by Nitz Gisele (2018-06-08)
by Schneiderman Schneiderman (2018-06-08)
by Esperanza Mcnicholas (2018-06-08)
by Cataldo Carina (2018-06-08)
by Cassi Brumbaugh (2018-06-08)
by Lezlie Kilby (2018-06-08)
by Disher Delorse (2018-06-08)
by Aichele Stucker (2018-06-08)
by Trezza Aquilino (2018-06-08)
by Donovan Gigi (2018-06-08)
by Brevard Nicholls (2018-06-08)
by Sumler Jannette (2018-06-08)
by Davenport Siegal (2018-06-08)
by Lacourse Nicholls (2018-06-08)
by Roxann Emanuel (2018-06-08)
by Tressa Gale (2018-06-08)
by Kierstead Grayce (2018-06-09)
by Grayce Groman (2018-06-09)
by Nicholls Siegal (2018-06-09)
by Kilby Ladawn (2018-06-09)
by Arlene Mcquiston (2018-06-09)
by Renea Azar (2018-06-09)
by Nurse Maxima (2018-06-09)
by Jolliff Goold (2018-06-09)
by Arlene Dung (2018-06-09)
by Roseline Adela (2018-06-09)
by Babette Racquel (2018-06-09)
by Ruland Allyson (2018-06-09)
by Jauregui Brevard (2018-06-09)
by Azar Lehto (2018-06-09)
by Shofner Aichele (2018-06-09)
by Esterly Bryant (2018-06-09)
by Crista Aichele (2018-06-09)
by Kris Fredda (2018-06-09)
by Gale Racquel (2018-06-09)
by Renwick Rosena (2018-06-09)
by Wentzell Emanuel (2018-06-09)
by Luu Kimble (2018-06-09)
by Ruben Stucker (2018-06-10)
by Chesser Doloris (2018-06-10)
by Terresa Doloris (2018-06-10)
by Lemon Babette (2018-06-10)
by Davenport Kris (2018-06-10)
by Lezlie Wentzell (2018-06-10)
by Stlouis Treva (2018-06-10)
by Johnette Delaine (2018-06-10)
by Vandermolen Bev (2018-06-10)
by Johnathan Jantz (2018-06-10)
by Cesar Treva (2018-06-10)
by Lasonya Vance (2018-06-10)
by Siegal Destiny (2018-06-10)
by Rosalee Leonida (2018-06-10)
by Millsaps Treva (2018-06-10)
by Tressie Fredda (2018-06-10)
by Bird Tammi (2018-06-10)
by Willis Kilby (2018-06-10)
by Mcquiston Cataldo (2018-06-10)
by Nies Racquel (2018-06-10)
by Mcquiston Shira (2018-06-10)
by Seegmiller Deno (2018-06-10)
by Delorse Duong (2018-06-10)
by Treva Vanness (2018-06-10)
by Vance Nitz (2018-06-10)
by Vernita Brooks (2018-06-10)
by Susana Kathy (2018-06-10)
by Esperanza Azar (2018-06-10)
by Cuomo Janita (2018-06-10)
by Kierstead Sumiko (2018-06-10)
by Sanjuana Javier (2018-06-10)
by Latricia Azar (2018-06-10)
by Andrade Allyson (2018-06-11)
by Ruben Hession (2018-06-11)
by Esteban Vernita (2018-06-11)
by Vanness Arlinda (2018-06-11)
by Cesar Bev (2018-06-11)
by Javier Wentzell (2018-06-11)
by Neta Synthia (2018-06-11)
by Ruland Azar (2018-06-11)
by Luu Maribeth (2018-06-11)
by Esperanza Jannette (2018-06-11)
by Redus Donald (2018-06-11)
by Leonida Bryant (2018-06-11)
by Esperanza Eyman (2018-06-11)
by Star Goudy (2018-06-11)
by Babette Korn (2018-06-12)
by Donald Doloris (2018-06-12)
by Atilano Lawver (2018-06-12)
by Jiles Shanon (2018-06-12)
by Mcnicholas Cesar (2018-06-12)
by Dung Susana (2018-06-12)
by Chesser Daphne (2018-06-12)
by Renea Rees (2018-06-12)
by Bird Cesar (2018-06-12)
by Jauregui Susana (2018-06-12)
by Nies Tressa (2018-06-12)
by Cesar Ruland (2018-06-12)
by Johnathan Tusing (2018-06-12)
by Benner Star (2018-06-12)
by Stucker Matsuda (2018-06-12)
by Mcquiston Esperanza (2018-06-12)
by Lezlie Jannette (2018-06-12)
by Livers Allyson (2018-06-12)
by Daphne Allie (2018-06-12)
by Edington Racquel (2018-06-12)
by Grayce Esterly (2018-06-12)
by Groman Willis (2018-06-12)
by Kilby Allie (2018-06-12)
by Neal Barnes (2018-06-12)
by Roxann Bev (2018-06-13)
by Latricia Freyer (2018-06-13)
by Chesser Susana (2018-06-13)
by Lando Esperanza (2018-06-13)
by Wentzell Genoveva (2018-06-13)
by Goold Jannette (2018-06-13)
by Gisele Avelina (2018-06-13)
by Destiny Carl (2018-06-13)
by Synthia Brevard (2018-06-13)
by Siegal Schechter (2018-06-13)
by Brooke Adell (2018-06-13)
by Ruben Keva (2018-06-13)
by Delorse Synthia (2018-06-13)
by Duong Renwick (2018-06-13)
by Shira Siegal (2018-06-13)
by Lucilla Kirk (2018-06-13)
by Latricia Duong (2018-06-13)
by Kierstead Aichele (2018-06-13)
by Barnes Mcquiston (2018-06-13)
by Cassi Enciso (2018-06-13)
by Shanon Cory (2018-06-13)
by Racquel Aquilino (2018-06-13)
by Brooks Shawnna (2018-06-13)
by Redus Lawver (2018-06-13)
by Silber Lando (2018-06-13)
by Desrosier Edgar (2018-06-13)
by Lynsey Ritchie (2018-06-13)
by Esperanza Rosalee (2018-06-13)
by Gregoria Bryant (2018-06-13)
by Freyer Emanuel (2018-06-13)
by Delaine Gannon (2018-06-13)
by Aichele Jauregui (2018-06-13)
by Lawver Louetta (2018-06-13)
by Bev Neta (2018-06-13)
by Natashia Gigi (2018-06-13)
by Arlene Grayce (2018-06-13)
by Mae Trapani (2018-06-13)
by Seegmiller Roland (2018-06-13)
by Schneiderman Tusing (2018-06-14)
by Aquilino Lucilla (2018-06-14)
by Lasonya Dolores (2018-06-14)
by Gigi Atilano (2018-06-14)
by Ruland Matsuda (2018-06-14)
by Goudy Cooley (2018-06-14)
by Cassi Enciso (2018-06-14)
by Carl Duong (2018-06-14)
by Susana Willis (2018-06-14)
by Enciso Vanness (2018-06-14)
by Desrosier Kimble (2018-06-14)
by Eyman Mae (2018-06-14)
by Jantz Brooks (2018-06-14)
by Edgar Brumbaugh (2018-06-14)
by Sandridge Renea (2018-06-14)
by Esperanza Lynsey (2018-06-14)
by Rees Sumler (2018-06-14)
by Kris Lance (2018-06-14)
by Mitchell Demaris (2018-06-14)
by Doloris Johnathan (2018-06-14)
by Kimble Dematteo (2018-06-14)
by Lynsey Kinnaird (2018-06-14)
by Nicholls Silber (2018-06-15)
by Shawnna Star (2018-06-15)
by Maclean Keith (2018-06-15)
by Shanon Doloris (2018-06-15)
by Valencia Doloris (2018-06-15)
by Krieger Lucilla (2018-06-15)
by January Carina (2018-06-15)
by Norsworthy Valencia (2018-06-15)
by Lezlie Arlene (2018-06-15)
by Arrieta Groman (2018-06-15)
by Jiles Trapani (2018-06-15)
by Sadie Garrigan (2018-06-15)
by Jolliff Roland (2018-06-15)
by Stanton Lucilla (2018-06-15)
by Tressa Norsworthy (2018-06-15)
by JulianaHilário Barros (2018-06-15)
by Fredda Groman (2018-06-15)
by AliciaBotelho Frutuoso (2018-06-15)
by Kinnaird Goudy (2018-06-16)
by Lasonya Nies (2018-06-16)
by Chesser Matsuda (2018-06-16)
by Jantz Mae (2018-06-16)
by Mcnicholas Disher (2018-06-16)
by Trapani Hession (2018-06-16)
by Grisel Brooks (2018-06-16)
by Rees Tressie (2018-06-16)
by Ruland Jauregui (2018-06-16)
by Bev Kathy (2018-06-16)
by Gigi Goold (2018-06-16)
by Cooley Louetta (2018-06-16)
by Carrera Cesar (2018-06-17)
by Babette Delaine (2018-06-17)
by Maribeth Wentzell (2018-06-17)
by Tressie Voltz (2018-06-17)
by Racquel Tressa (2018-06-17)
by Earwood Livers (2018-06-17)
by Demaris Gregoria (2018-06-17)
by Disher Johnathan (2018-06-17)
by Jantz Emanuel (2018-06-17)
by Nurse Roseline (2018-06-17)
by Hession Rosena (2018-06-17)
by Lucilla Lynsey (2018-06-17)
by Maclean Goold (2018-06-18)
by Ruland Freyer (2018-06-18)
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