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Keywords bioinformatics breast cancer breast carcinoma cancer case report chemotherapy cisplatin epidemiology immunotherapy mutation non-small cell lung cancer omics oncology ovarian cancer prostate cancer radiotherapy rectal cancer survival targeted therapy therapy treatment
Home > Vol 3, No 3 (2017) > Eltanani

Endothelial cell metabolism inhibition: A new approach to the treatment of resistant metastatic colorectal carcinoma

Abstract - 1655 PDF - 524
Shaimaa I Eltanani, Ahmed S Ibrahim

Abstract


March has been officially dedicated as National Colorectal Cancer (CRC) Awareness Month. This is important, as CRC incidence is now dramatically increasing in many developing countries that are undergoing major economic transition.


Keywords


colorectal carcinoma; Warburg effect; GLUT1; fatty acid metabolism; glycolysis; endothelial cells; VEGF; CRC; Aflibercept

Full Text:

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References


Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R, Mariani-Costantini R. Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol 2014; 20(20): 6055–6072. doi: 10.3748/wjg.v20.i20.6055.


Hurwitz H, Kabbinavar F. Bevacizumab combined with standard fluoropyrimidine-based chemotherapy regimens to treat colorectal cancer. Oncology 2005; 69(Suppl 3): 17–24. doi: 10.1159/000088480.


Schellerer VS, Croner RS, Weinländer K, Hohenberger W, Stürzl M, et al. Endothelial cells of human colorectal cancer and healthy colon reveal phenotypic differences in culture. Lab Invest 2007; 87(11): 1159–1170. doi: 10.1038/labinvest.3700671.


National Comprehensive Cancer Network (NCCN). Guidelines for patients: Colon cancer; Version 1.2016[Internet]. Fort Washington, PA, USA: NCCN; 2016 [cited 2017 Feb 15]. Available from: https://www.nccn.org/patients/guidelines/colon/index.html.


Holzner S, Senfter D, Stadler S, Staribacher A, Nguyen CH, et al. Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro. Oncol Rep 2016; 36(5): 3065–3071. doi: 10.3892/or.2016.5114.


Anklesaria P, Salimi A, Greenberger JS, Griffin TW. Carcinoembryonic antigen (CEA) mediates adhesion of colorectal cancer cells to human bone marrow stroma and endothelial cells. Mol Biol Cell 1992; 3(Suppl 287a–326a): A290. doi: 10.1091/mbc.3.Suppl.287a.


Hong BS, Cho JH, Kim HJ, Choi EJ, Rho SC, et al. Colorectal cancer cell-derived microvesicles are enriched in cell cycle related mRNAs that promote proliferation of endothelial cells. BMC Genomics, 2009. 10: 556. doi: 10.1186/1471-2164-10-556.


Zaytseva YY, Elliott VA, Rychahou P, Mustain WC, Kim JT, et al. Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. Carcinogenesis 2014; 35(6): 1341–1351. doi: 10.1093/carcin/bgu042.


De Bock K, Georgiadou M, Carmeliet P. Role of endothelial cell metabolism in vessel sprouting. Cell Metab 2013; 18(5): 634–647. doi: 10.1016/j.cmet.2013.08.001.


Yeluri S, Madhok B, Prasad KR, Perry SL, Thorpe H, et al. The mediators of warburg’s effect in colorectal cancer: Targets for future therapy. Br J Surg 2010; 97(S6): 32. doi: 10.1002/bjs.7351.


De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell 2013; 154(3): 651–663. doi: 10.1016/j.cell.2013.06.037.


Harjes U, Kalucka J, Carmeliet P, Targeting fatty acid metabolism in cancer and endothelial cells. Crit Rev Oncol Hematol 2016; 97:15–21. doi: 10.1016/j.critrevonc.2015.10.011


Yeh WL, Lin CJ, Fu WM. Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia. Mol Pharmacol 2008; 73(1): 170–177. doi: 10.1124/mol.107.038851.


Parra-Bonilla G, Alvarez DF, Al-Mehdi AB, Alexeyev M, Stevens T. Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation. Am J Physiol Lung Cell Mol Physiol 2010; 299(4): L513–L522. doi: 10.1152/ajplung.00274.2009.


Zhang D, Fei Q, Li J, Zhang C, Sun Y, et al. 2-deoxyglucose reverses the promoting effect of insulin on colorectal cancer cells in vitro. PLoS One 2016; 11(3): e0151115. doi: 10.1371/journal.pone.0151115.


Aguilera O, Muñoz-Sagastibelza M, Torrejón B, Borrero-Palacio A, del Puerto-Nevado L, et al. Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. Oncotarget 2016; 7(30): 47954–47965. doi: 10.18632/oncotarget.10087.


Li T, Gao X, Yang L, Shi Y, Gao Q. Methyl 6-amino-6-deoxyd-pyranoside-conjugated platinum(II) complexes for glucose transporter (GLUT)-mediated tumor targeting: Synthesis, cytotoxicity, and cellular uptake mechanism. ChemMedChem 2016; 11(10): 1069–1077. doi: 10.1002/cmdc.201600079.


Hussain A, Qazi AK, Mupparapu N, Guru SK, Ashok Kumar A, et al. Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth. Cancer Lett 2016; 374(2): 250–260. doi: 10.1016/j.canlet.2016.02.030.


Jia Y, Ma Z, Liu X, Zhou W, He S, et al. Metformin prevents DMH-induced colorectal cancer in diabetic rats by reversing the warburg effect. Cancer Med 2015; 4(11): 1730–1741. doi: 10.1002/cam4.521.


Liu Y, Cao Y, Zhang W, Bergmeier S, Qian Y, et al. A small molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther 2012; 11(8): 1672–1682. doi: 10.1158/1535-7163.MCT-12-0131.


Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med 2011; 3(94): 94ra70. doi: 10.1126/scitranslmed.3002394.


Liu R, Fu Z, Zhao M, Gao X, Li H, et al. GLUT1-mediated selective tumor targeting with fluorine containing platinum(II) glycoconjugates. Oncotarget 2017. In Press. doi: 10.18632/oncotarget.17073.


Han J, Gao X, Liu R, Yang J, Zhang Z, et al. Design, synthesis of novel platinum(II) glycoconjugates, and evaluation of their antitumor effects. Chem Biol Drug Des 2016; 87(6): 867–877. doi: 10.1111/cbdd.12718.


Cervantes‑Madrid D, Dominguez‑Gomez G, Gonzalez‑Fierro A, Perez‑Cardenas E, Taja‑Chayeb L, et al. Feasibility and antitumor efficacy in vivo, of simultaneously targeting glycolysis, glutaminolysis and fatty acid synthesis using lonidamine, 6-diazo-5-oxo-L-norleucine and orlistat in colon cancer. Oncol Lett, 2017; 13(3):1905–1910. doi: 10.3892/ol.2017.5615





DOI: http://dx.doi.org/10.18282/amor.v3.i3.206

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