Home About Login Register Search Archives Announcements

 

Aim and Scope

To provide communication and information exchanging platforms for a broad audience of oncologists, surgeons, medical researchers and professionals working in the field.

Editor-in-Chief

Prof. Dr. Kwong-Kwok Wong
The University of Texas MD Anderson Cancer Center

User
Submit Your Manuscript

Downloads

Manuscript Submission Template

ICMJE Conflict of Interest Form

Article Tools
Print this article
Indexing metadata
How to cite item
Finding References
Email this article (Login required)
Email the author (Login required)
Post a Comment (Login required)

Tweets by @AMOR_PiscoMed

Home > Vol 3 (2017) > Liu

Healthcare-associated infections among patients with different types of acute leukemia in China: A surveillance-based study

Abstract - 178 PDF - 47
Yunhong Liu, Tianyuan Yan, Jingna Wang, Carmen WH Chan, Doris YP Leung, Shuhui Wang

Abstract


Healthcare-associated infections (HAIs) may be diverse among patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). However studies were limited. We aimed to quantify and compare the characteristics and relevant factors associated with HAIs among patients with AML and ALL. The surveillance-based study was conducted in a university teaching hospital. All adult patients diagnosed with acute leukemia (AL) and admitted into the Hematology Department for over 48 h were included. HAI characteristics and relevant factors were compared between AML and ALL patients. A consecutive sample of 994 patients with AL was recruited. The proportions of infected cases (27.78% vs. 28.31%, p = 0.888) and the HAI incidence (21.29 vs. 22.82 per 1,000 patient-days at risk, p = 0.733) were comparable among AML and ALL patients, respectively. Compared with ALL patients, higher risks of HAIs were found among AML patients with increasing duration of chemotherapy or lower hemoglobin level. Meanwhile, increased length of stays during previous cycles of chemotherapy, lower level of platelets, and diabetes were associated with higher risks of HAIs among ALL patients compared with AML patients. In conclusion, our results found that AML and ALL patients experienced different risks of HAIs associated with diverse relevant factors. Future multi-center studies are needed to provide stronger evidence.

Keywords


acute myeloid leukemia; acute lymphoblastic leukemia; healthcare-associated infections; relevant factors of infections

Full Text:

PDF

References


Ford CD, Lopansri BK, Haydoura S, Snow G, Dascomb KK, et al. Frequency, risk factors, and outcomes of vancomycin resistant enterococcus colonization and infection in patients with newly diagnosed acute leukemia: Different patterns in patients with acute myelogenous and acute lymphoblastic leukemia. Infect Control Hosp Epidemiol 2015; 36(1): 47−53. doi: 10.1017/ice.2014.3.


Healthcare-associated infections [Internet]. Sweden: European Centre for Disease Prevention and Control; 2005–2017 [cited 2017 March 23]. Available from: http:// http://ecdc.europa.eu/en/healthtopics/Healthcare-associated_infections/Pages/index. aspx.


Wang J. Study on the risk factors and direct economic losses of nosocomial infection with acute leukemia patients [Dissertation]. China: Shandong University; 2014.


Sabattini E, Bacci F, Sagramoso C, Pileri SA. WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: An overview. Pathologica 2010; 102(3): 83−87.


Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol 1976; 33(4): 451−458. doi: 10.1111/j.1365-2141.1976.tb03563.x.


DeAngelo DJ, Pui C. Acute lymphoblastic leukemia and lymphoblastic lymphoma. 6th ed. In: American Society of Hematology Self-Assessment Program. Washington: American Society of Hematology. 2013. p. 491–507.


Gooley TA, Chien JW, Pergam SA, Hingorani S, Sorror ML, et al. Reduced mortality after allogeneic hematopoietic-cell transplantation. N Engl J Med 2010; 363(22): 2091−2101. doi: 10.1056/NEJMoa1004383.


Pulte D, Gondos A, Brenner H. Trends in 5- and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990–2004. J Natl Cancer Inst 2008; 100(18): 1301−1309. doi: 10.1093/jnci/djn276.


Huoi C, Vanhems P, Nicolle MC, Michallet M, Benet T. Incidence of hospital-acquired pneumonia, bacteraemia and urinary tract infections in patients with haematological malignancies, 2004-2010: A surveillance-based study. PLoS One 2013; 8(3): e58121. doi: 10.1371/journal.pone.0058121.


Thirumala R, Ramaswamy M, Chawla S. Diagnosis and management of infectious complications in critically ill patients with cancer. Crit Care Clin 2010; 26(1): 59−91. doi: 10.1016/j.ccc.2009.09.007.


Crawford J, Dale DC, Lyman GH. Chemotherapy-induced neutropenia: Risks, consequences, and new directions for its management. Cancer 2004; 100(2): 228−237. doi: 10.1002/cncr.11882.


Alatorre-Fernández P, Mayoral-Terán C, Velázquez-Acosta C, Franco-Rodríguez C, Flores-Moreno K, et al. A polyclonal outbreak of bloodstream infections by Enterococcus faecium in patients with hematologic malignancies. Am J Infect Control 2017; 45(3): 260−266. doi: 10.1016/j.ajic.2016.10.002.


Bow EJ, Rotstein C, Noskin GA, Laverdiere M, Schwarer AP, et al. A randomized, open-label, multicenter comparative study of the efcacy and safety of piperacillin-tazobactam and cefepime for the empirical treatment of febrile neutropenic episodes in patients with hematologic malignancies. Clin Infect Dis 2006; 43(4): 447−459. doi: 10.1086/505393.


Dettenkofer M, Ebner W, Bertz H, Babikir R, Finke U, et al. Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation. Bone Marrow Transpl 2003; 31(9): 795−801. doi: 10.1038/sj.bmt.1703920.


Urrea M, Rives S, Cruz O, Navarro A, Garcia JJ, et al. Nosocomial infections among pediatric hematology/oncology patients: Results of a prospective incidence study. Am J Infect Control 2004; 32(4): 205−208. doi: 10.1016/j.ajic.2003.10.013.


Dettenkofer M, Wenzler-Röttele S, Babikir R, Bertz H, Ebner W, et al. Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant: A multicenter project. Clin Infect Dis 2005; 40(9): 926−931. doi: 10.1086/428046.


Al-Tonbary YA, Soliman OE, Sarhan MM, Hegazi MA, ElAshry RA, et al. Nosocomial infections and fever of unknown origin in pediatric hematology/oncology unit: A retrospective annual study. World J Pediatr 2011; 7(1): 60−64. doi: 10.1007/s12519-010-0212-1.


Semochkin SV, Tolstykh TN, Arkhipova NV, Ivanova VL, Kliueva OV, et al. Clinical and epidemiological characteristics of acute myeloid leukemias in adults according to the data of municipal hematology departments in Moscow. Ter Arkh 2015; 87(7): 26−32. doi: 10.17116/terarkh201587726-32.


Giri S, Chi M, Johnson B, McCormick D, Jamy O, et al. Secondary acute lymphoblastic leukemia is an independent predictor of poor prognosis. Leuk Res 2015; 39(12): 1342−1346. doi: 10.1016/j.leukres.2015.09.011.


Karachunskiĭ AI, Rumiantseva IuV, Lagoĭko SN, Bührer C, Tallen G, et al. Age-related characteristics of the efficacy of different glucocorti-costeroids in the therapy of acute lymphoblastic leukemia. Ter Arkh 2015; 87(7): 41−50.


Garcia JB, Lei X, Wierda W, Cortes JE, Dickey BF, et al. Pneumonia during remission induction chemotherapy in patients with acute leukemia. Ann Am Thorac Soc 2013; 10(5): 432−440. doi: 10.1513/AnnalsATS.201304-097OC.


Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008; 36(5): 309−332. doi: 10.1016/j.ajic.2008.03.002.


Liu H, Zhao J, Xing Y, Li M, Du M, et al. Nosocomial infection in adult admissions with hematological malignancies originating from different lineages: A prospective observational study. PLoS One 2014; 9(11): e113506. doi: 10.1371/journal.pone.0113506.


Biswal S, Godnaik C. Incidence and management of infections in patients with acute leukemia following chemotherapy in general wards. Ecancermedicalscience 2013; 7: 310. doi: 10.3332/ecancer.2013.310.


Li C, Li J, Li Y, Lang S, Yougbare I, et al. Crosstalk between platelets and the immune system: Old systems with new discoveries. Adv Hematol 2012: 384685.doi: 10.1155/2012/384685.


Ilavská S, Horváthová M, Szabová M, Nemessányi T, Jahnová E, et al. Association between the human immune response and body mass index. Hum Immunol 2012; 73(5): 480−485. doi: 10.1016/j.humimm.2012.02.023.


Shafey A, Ethier MC, Traubici J, Naqvi A, Sung L. Incidence, risk factors, and outcomes of enteritis, typhlitis, and colitis in children with acute leukemia. Int J Pediatr Hematol Oncol 2013; 35(7): 514−517. doi: 10.1097/MPH.0b013e31829f3259.


Berrueco R, Rives S, Catala A, Toll T, Gene A, et al. Prospective surveillance study of blood stream infections associated with central venous access devices (port-type) in children with acute leukemia: An intervention program. J Pediatr Hematol Oncol 2013; 35(5): e194–e199. doi: 10.1097/MPH.0b013e318290c24f.


Mühlemann K, Wenger C, Zenhäusern R, Täuber MG. Risk factors for invasive aspergillosis in neutropenic patients with hematologic malignancies. Leukemia 2005; 19(4): 545−550. doi: 10.1038/sj.leu.2403674.


Ekiz C, Agaoglu L, Karakas Z, Gurel N, Yalcin I. The effect of iron defciency anemia on the function of the immune system. Hematol J 2005; 5(7): 579−583. doi: 10.1038/sj.thj.6200574.


Dare JM, Moppett JP, Shield JP, Hunt LP, Stevens MC. The impact of hyperglycemia on risk of infection and early death during induction therapy for acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer 2013; 60(12): e157−e159. doi: 10.1002/pbc.24689.


Ali NA, O’Brien JM, Blum W, Byrd JC, Klisovic RB, et al. Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality. Cancer 2007; 110(1): 96−102. doi: 10.1002/cncr.22777.





DOI: http://dx.doi.org/10.18282/amor.v3.is1.211

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Bookmark and Share
                                       

© 2017 by PiscoMed Publishing Pte Ltd