Home About Login Register Search Archives Announcements

 

Aim and Scope

To provide communication and information exchanging platforms for a broad audience of oncologists, surgeons, medical researchers and professionals working in the field.

Editor-in-Chief

Prof. Dr. Kwong-Kwok Wong
The University of Texas MD Anderson Cancer Center

Indexing and Archiving

Advances in Modern Oncology Research is currently indexed in:

-CAS

  • -CNKI
  • -J-gate
  • -Directory of Open Access Journals (DOAJ)
  • -Google Scholar


AMOR is archived by Portico and the National Library Board of Singapore.

User
Submit Your Manuscript

Downloads

Manuscript Submission Template

ICMJE Conflict of Interest Form

Events

Article Tools
Print this article
Indexing metadata
How to cite item
Finding References
Email this article (Login required)
Email the author (Login required)
Post a Comment (Login required)

Tweets by @AMOR_PiscoMed

Keywords bioinformatics breast cancer breast carcinoma cancer case report chemotherapy cisplatin epidemiology immunotherapy mutation non-small cell lung cancer omics oncology ovarian cancer prostate cancer radiotherapy rectal cancer survival targeted therapy therapy treatment
Home > Vol 3, No 6 (2017) > Ch'ng

The incidence of ototoxicity in children receiving cisplatin in Hospital Pulau Pinang

Abstract - 1116 PDF - 354
Pao Pao Ch'ng, Siti Fatimah, Mei Mei Koid, Muna binti Martadza

Abstract


Background: Since the establishment of oncology unit in Hospital Pulau Pinang, no study has been conducted to determine the incidence of ototoxicity among pediatric patients receiving cisplatin as part of their chemotherapy treatment. The risk factor that was believed to result to ototoxicity events was reported inconsistently. In one study, the prevalence rate of cisplatin-induced sensorineural hearing loss ranging from 10% to 85% of children studied. This study aimed to determine the incidence of cisplatin-induced ototoxicity (OTX) among pediatric patients in Hospital Pulau Pinang (HPP) and to determine the association of risk factors of cisplatin induced ototoxicity (OTX) among pediatric patients in Hospital Pulau Pinang (HPP). Methodology: A retrospective study was conducted on a total of 68 pediatric patients. The incidence of ototoxicity between September 2009 and August 2015 was determined. The association between the ototoxicity incidence and age, gender, cumulative dose and type of cancer were analyzed using Chi-square test. Results: A total of 26 patients which fulfilled the inclusion criteria were included in the study. The incidence of ototoxicity was 53.8% (n = 14). There were no significant association between age when starting cisplatin (χ2 = 7.066, p = 0.07), gender (p = 0.431) and type of cancer (χ2 = 2.547, p = 0.467) with the hearing status of the patient. There was a significant association between cumulative doses of cisplatin with hearing status of the patients (p<0.05). Conclusion: The incidence of ototoxicity is alarming among pediatrics receiving cisplatin. Hearing assessment should be conducted as per chemotherapy protocol in the attempt to serve as early efforts to minimize ototoxicity induced by cisplatin. NMRR ID: NNMR-15-1565-26151

Keywords


cisplatin; ototoxicity; pediatrics; risk factors

Full Text:

PDF


DOI: http://dx.doi.org/10.18282/amor.v3.i6.277

Refbacks

  • There are currently no refbacks.

Comments on this article

  • Good
    by Mike David (2018-03-09)
  • Good
    by Mike David (2018-03-09)
  • legal o artigo
    by MariaVitoriaSales Crespo (2018-06-15)
  • Muito bom
    by EduardaCavalcante Almada (2018-06-30)
  • O Que É? Funciona? Onde Posso Comprar?
    by MariaVitoriaParis Fogaça (2018-06-30)
  • Assignment Writing Service
    by voilet taylor (2018-07-04)
  • Informative
    by Jone James (2018-08-07)
  • O Que Brasil E Itália Têm Em Comum
    by Madison Bigelow (2018-09-18)
  • ↑ «Atividades Econômicas Em Macapá (2018)»
    by Cherie Soileau (2018-09-19)
  • Floricultura Em Curitiba Compre Online
    by Cherie Soileau (2018-09-23)
  • Fórum Dos Leitores
    by Alannah Armour (2018-09-23)
  • #destinocopa2018 #copa2018 #parana #turismo #rpr
    by Leandro Gonsalves (2018-09-23)
  • Saiba Como Será O City Tour Oficial De São Paulo
    by Brigette McKelvey (2018-09-25)
  • 39 Concursos Públicos Pagam Salários De Até R$ vinte e sete,5 1 mil
    by Tom Gollan (2018-09-29)
  • greatpeople
    by velevobowi gifto (2018-11-09)
View all comments


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Bookmark and Share
                                       

© 2017 by PiscoMed Publishing Pte Ltd